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Our data analysis showed the overall cancer detection rate for the one-time approach was greatest for MRI-B (376%) compared with both TS-B (300%) and TP-B (368%). Importantly however, in a sensitivity analysis including only those studies that used more than three biopsy cores per patient, there was no significant difference in cancer detection between the three strategies (p = 0.78). This result suggests that in a real-life clinical setting where the number of cores taken per patient may vary, the actual benefit of each individual approach on cancer detection rates will be minimal. We hypothesise that if a second-level re-biopsy was performed immediately after first biopsy, any cancer missed at the first biopsy would have been recognised at the repeat biopsy reducing the cancer detection rate between the two procedures.

There was little difference in the median number of biopsy cores taken between the different MRI modalities as the figures varied between 7 and 11. There were no significant differences in cancer detection between the techniques, and in each case, the highest cancer detection was shown by MRI-B. However, when the studies were re-analysed to only include those studies in which there were more than three biopsy cores per patient, there was no significant difference in cancer detection between MRI-B and TP-B or TP-B and TS-B (p = 0.66 and p = 0.12 respectively).

This means that the highest cancer detection rates are achieved not by increasing the number of biopsies performed, but by increasing the number of cores taken per patient. Furthermore, when only those patients where more than three biopsies were performed were included, there were no significant differences in cancer detection rates between the MRI strategies. Importantly however, in real life scenarios where the number of cores taken per patient may vary, the actual benefit of each individual approach on cancer detection rates will be minimal. We hypothesise that in a real-life clinical setting where the number of cores taken per patient may vary, the actual benefit of each individual approach on cancer detection rates will be minimal.

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